Catabolism of 4‐hydroxy‐2(E)‐nonenal (HNE) via omega oxidation in perfused rat livers
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چکیده
منابع مشابه
Metabolism of γ-hydroxybutyrate in perfused rat livers.
GHB (γ-hydroxybutyrate) is both a neurotransmitter and a drug of abuse (date-rape drug). We investigated the catabolism of this compound in perfused rat livers. Using a combination of metabolomics and mass isotopomer analysis, we showed that GHB is metabolized by multiple processes, in addition to its previously reported metabolism in the citric acid cycle via oxidation to succinate. A substrat...
متن کاملHepatic disposition of cyclosporine A in isolated perfused rat livers.
PURPOSE To develop an isolated perfused rat liver model to study the hepatic disposition of cyclosporine A (CyA) in both sexes. METHODS Livers were isolated from male (n = 6) and female (n = 7) rats and perfused with a physiological buffer in a single-pass manner. A bolus 1-mg dose of CyA was injected into the inlet catheter and periodical samples (0-15 min) were collected from the outlet per...
متن کاملProtein catabolism and protein synthesis in perfused livers of normal and alloxan-diabetic rats.
Profound changes in protein metabolism noted in diabetes mellitus are grossly reflected in a negative nitrogen balance. It is not clear whether this is due to depressed protein synthesis or to increased protein catabolism. Turnover studies with N15glycine have been interpreted to favor an effect on synthesis (1). Krahl (2) has demonstrated that liver slices from diabetic rats have a decreased c...
متن کاملCatabolism of plasma albumin by the perfused rat liver.
The liver is known to be a major site of plasmaprotein synthesis, but there is little information concerning its role in the catabolism of native plasma proteins. The ease with which the isolated perfused liver can be maintained under physiological conditions would appear to make it an ideal system for studying plasma-protein breakdown. However, the ability of the liver to take up particulate m...
متن کاملOmega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes.
Leukotriene B4 (LTB4), formed by the 5-lipoxygenase pathway in human polymorphonuclear leukocytes (PMN), may be an important mediator of inflammation. Recent studies suggest that human leukocytes can convert LTB4 to products that are less biologically active. To examine the catabolism of LTB4, we developed (using high performance liquid chromatography) a sensitive, reproducible assay for this m...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.794.15